FABP4 Attenuates PPAR and Adipogenesis and Is Inversely Correlated With PPAR in Adipose Tissues
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چکیده
منابع مشابه
FABP4 attenuates PPARγ and adipogenesis and is inversely correlated with PPARγ in adipose tissues.
Fatty acid binding protein 4 (FABP4, also known as aP2) is a cytoplasmic fatty acid chaperone expressed primarily in adipocytes and myeloid cells and implicated in the development of insulin resistance and atherosclerosis. Here we demonstrate that FABP4 triggers the ubiquitination and subsequent proteasomal degradation of peroxisome proliferator-activated receptor γ (PPARγ), a master regulator ...
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Fatty acid binding protein 4 (FABP4, also known as aP2) is a cytoplasmic fatty acid chaperone expressed primarily in adipocytes and myeloid cells and implicated in the development of insulin resistance and atherosclerosis. Here we demonstrate that FABP4 triggers the ubiquitination and subsequent proteasomal degradation of peroxisome proliferator–activated receptor g (PPARg), a master regulator ...
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Fatty acids (FAs) are known to be important regulators of insulin secretion from pancreatic -cells. FA-coenzyme A esters have been shown to directly stimulate the secretion process, whereas long-term exposure of -cells to FAs compromises glucose-stimulated insulin secretion (GSIS) by mechanisms unknown to date. It has been speculated that some of these long-term effects are mediated by members ...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2013
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db13-0436